Fetal MRI Alobar Holoprosencephaly

Case:
# 5049762318
Section:
Author(s):


Donato, Angel MD. Huapaya, Janice MD. Figueroa, Ramon E. MD. FACR

Augusta University 
1120 15th street
Augusta, GA 30912
USA
Email:donatoangel@yahoo.com

Patient:
Female, 29 year(s)

CLINICAL HISTORY

29 year old female with abnormal fetal ultrasound examination.


IMAGING FINDINGS

Fetal MRI shows a borderline small intracranial volume with a T2 low signal behavior brainstem and midline fused thalamic nuclear mass centrally (Figure 1 ), surrounded by T2 hyperintense faintly visualized cerebellar hemispheres in the infratentorial compartment (Figure 2) and T2 hyperintense cerebral hemispheres in the supratentorial compartment. There is abnormal loss of fetal hemisphere definition, suggesting a bilateral global monoventricle with preservation of superficial cortical surface (Figure 3). The T2 hypointense basal nuclei are otherwise poorly defined, such as seen in fused thalami with no recognizable morphology. There are no definable lateral and third ventricles with common space in keeping with a large monoventricle. There is poor development of the facial structures and orbits with a rudimentary ocular structure centrally positioned (Figure 4) at the root of the proboscis (Figure 5) suggesting a cyclops morphology.

IMAGES